SMEDDS is an acronym for Self Micro-Emulsifying Drug Delivery System. SMEDDS formulations are a clear solution of a drug substance which spontaneously form an oil-in water (O/W) microemulsion upon dispersion in water. In the emulsion the drug substance is incorporated within droplets with a size of 50-200 µm. A SMEDDS formulation typically contains a lipid solvent, one or more surfactants and optionally a co-solvent.